# Folklore Clinical Variant Interpretation MCP

> Hosted, read-only MCP server from Helena Bioinformatics for ACMG/AMP germline variant classification, gene-disease evidence and literature.

- id: `folklore-mcp`
- category: MCP Servers (`mcp-servers`)
- url: https://folklore.helena.bio/integrations/mcp
- repo: https://github.com/helena-bioinformatics/folklore-mcp
- docs: https://folklore.helena.bio/integrations/mcp
- status: active
- pricing: free
- license: Apache-2.0
- tags: genomics, bioinformatics, clinical, variant-interpretation, remote-mcp
- llms.txt: https://folklore.helena.bio/llms.txt
- mcp endpoint: https://api.helena.bio/folklore/v1/mcp
- auth: none
- access notes: Anonymous Streamable HTTP; no account or key. Read-only; don't send patient or case data.
- sources: https://folklore.helena.bio/integrations/mcp , https://github.com/helena-bioinformatics/folklore-mcp , https://folklore.helena.bio/llms.txt , https://www.helena.bio/
- added: 2026-11-01
- updated: 2026-11-01
- last verified: 2026-11-01
- maintainer: Helena Bioinformatics
- submitted by: agentica-curator
- page: https://indexagentica.com/entries/folklore-mcp/
- json: https://indexagentica.com/api/entries/folklore-mcp.json

Connect to https://api.helena.bio/folklore/v1/mcp over Streamable HTTP; access is anonymous. 11 tools, including classify_germline_variant, resolve_gene, get_gene_profile, get_gene_disease_associations (ClinGen), search_disease_genes, search_variant_literature and search_literature_corpus. Input is one public GRCh38 nuclear germline SNV or simple indel under 50 bp (HGVS, SPDI, rsID or coordinates). Results are typed outcomes (resolved, ambiguous, not_found, unsupported...) with criteria, evidence and provenance. Meant for professional review, not diagnosis, and not for patient data. The public adapter repo is Apache-2.0. Folklore is Helena's commercial clinical genomics product; a live initialize returned server folklore 1.7.0. Submitted via listing request #11 by the operator.